Sports Injury Risk: Medications, Side Effects, and How to Stay Safe

When you think of sports injury risk, the chance of getting hurt during physical activity due to physical, environmental, or medical factors. Also known as exercise-related injury risk, it often gets blamed on poor form, weak muscles, or bad luck. But there’s another hidden factor: the medications you’re taking. Many common drugs—like benzodiazepines, antidepressants, and heart meds—can make you dizzy, sluggish, or unsteady, turning a simple sprint or jump into a fall waiting to happen.

Take fall risk medications, drugs that impair balance, coordination, or alertness, increasing the likelihood of accidental falls. These aren’t just for seniors. Athletes on sleep aids, anxiety meds, or even certain blood pressure pills may not realize their meds are stealing their reaction time. A study in the Journal of Sports Medicine found that people on benzodiazepines were 3x more likely to suffer ankle or knee injuries during training. And it’s not just falls. heart medication interactions, dangerous combinations of cardiovascular drugs that can cause dizziness, low blood pressure, or irregular heartbeat can sabotage your workout before you even step onto the field. Mixing a beta-blocker with a diuretic? That combo can drop your blood pressure too fast, leaving you lightheaded mid-squat.

Then there’s the silent killer: polypharmacy risks, the increased danger of side effects and interactions when taking multiple medications at once. An athlete on painkillers, muscle relaxants, and a sleep aid might think they’re managing their recovery—until they trip on a curb or pull a hamstring because their body’s too sedated to react. And it’s not just physical. Some antidepressants reduce motivation and energy, making you less likely to warm up properly or recover well. Side effects you’ve learned to live with—dry mouth, fatigue, blurred vision—might be quietly raising your sports injury risk every time you train.

You don’t have to quit your meds to stay active. But you do need to know which ones are working against you. The posts below break down exactly which drugs increase injury chances, how they do it, and what to ask your doctor to stay safe. You’ll find real-world guides on avoiding dangerous combos, spotting hidden side effects, and adjusting your routine so your health plan doesn’t become your biggest liability.